We study the molecular mechanisms underlying chemosensation and temperature sensation.
Lab News
- Our reviewed preprint on understudied CALHM channels is published at eLife today
Through our collaboration with the Kannan lab at the University of Georgia, we reveal conserved gating determinants in understudied CALHM ion channels using an evolutionary analysis approach combined with electrophysiology.
- Congratulations to Sarah on passing her Qualifying Exam
A major milestone — She is now officially a PhD candidate!
- Our preprint on agonist and heat activation of TRPM3 is now published in NSMB
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Latest Papers
Identification and classification of ion-channels across the tree of life provide functional insights into understudied CALHM channels
Taujale R$, Park SJ$, Gravel N, Soleymani S, Carter R, Boyd K, Keuning S, Ruan Z, Lü W#, Kannan N# (2025) eLife 14:RP106134.
Structural basis for agonist and heat activation of nociceptor TRPM3
Kumar S$, Jin F$, Park SJ, Choi W, Keuning S, Massimino R, Vu S, Lü W#, Du J# (2025) Nature Structural & Molecular Biology.
Human pannexin 1 channel is not phosphorylated by Src tyrosine kinase at Tyr199 and Tyr309
Ruan Z, Lee J, Li Y, Du J#, Lü W# (2024) eLife 13:RP95118.